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Connecticut’s state medical examiner has requested a full genetic analysis of mass killer Adam Lanza, who shot 20 children, 6 school staff, his mother and himself in Newtown in December. At first glance, it is easy to understand why. Confronted with such senseless violence, it is human nature to seek solace in scientific explanations. After John Wayne Gacy was executed in 1994 for the murder of 33 young men and boys, his brain was preserved and examined for clues to what made him a monster. More than 80 years ago, scientists reportedly studied the brain of serial killer Peter Kürten, the ‘vampire of Dusseldorf’, who was executed in 1931.

This quest to understand endures as technology advances. Now, instead of looking at cranial folds and frontal lobes for clues to the massacre, geneticists at the University of Connecticut in Farmington will scour Lanza’s genes. On its own, this hunt will be about as informative as studies of the brains of murderers: not very.

The Connecticut scientists will not talk about the job they have been handed. It is not clear...