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About Inheritable Genetic Modification


Human Germline Gene Editing

Frequently Asked Questions

Arguments Pro & Con

3-Person IVF

Inheritable genetic modification (IGM, also called germline engineering) means changing the genes passed on to future generations. The genetic changes would be made in eggs, sperm or early embryos; modified genes would appear not only in the person who developed from that gamete or embryo, but also in all succeeding generations. IGM has not been tried in humans. It would be by far the most consequential type of genetic modification as it would open the door to irreversibly altering the human species.

Proposals for inheritable genetic modification in humans combine techniques involving in vitro fertilization (IVF), gene transfer, stem cells and research cloning.



Written evidence for the Genomics and Genome-Editing Inquiry of the House of Commons Science and Technology Committee[cites CGS]by Edward Hockings and Lewis CoyneEthics and GeneticsJanuary 20th, 2017UK’s bioscience policy has been framed in terms of commercial value at the expense of substantive public consultation and broader deliberation.
How to Watch the Biggest Science Story of 2017by Leah LowthorpBiopolitical TimesJanuary 19th, 2017Less than three weeks into the new year, gene editing is already set to be one of the biggest stories of 2017. Here are three key points to watch out for.
Do We Need an International Body to Regulate Genetic Engineering?by Kristen V. BrownGizmodoJanuary 18th, 2017Science reaches across borders, which poses challenging questions for us to decide what the future should look like--locally and globally.
Controversial IVF technique produces a baby girl -- and for some, that's a problemby Susan ScuttiCNNJanuary 18th, 2017Stakes are rising as genetic modifications produced in a girl baby could be passed onto her future children. The risks remain unknown.
The Promise and Peril of Emerging Reproductive Technologiesby Ekaterina PeshevaHarvard Medical SchoolJanuary 11th, 2017IVG, thus far successful only in mice, allows scientists to create embryos in a lab by reprogramming any type of adult cell to become a sperm or egg cell.
How Gene Editing Could Ruin Human Evolution[cites CGS's Marcy Darnovsky]by Jim KozubekTimeJanuary 9th, 2017There are no superior genes. Genes have a long and layered history, and they often have three or four unrelated functions, which balance against each other under selection.
Designer babies: an ethical horror waiting to happen?by Philip BallThe Guardian January 8th, 2017A perfectly feasible 10-20% improvement in health via PGD, added to the comparable advantage that wealth already brings, could lead to a widening of the health gap between rich and poor, both within a society and between nations.
Rewriting the Code of Lifeby Michael SpecterNew YorkerJanuary 2nd, 2017Combining gene drive and CRISPR/Cas9 technologies, Kevin Esvelt is in an unusual position. There has never been a more powerful biological tool, or one with more potential to both improve the world and endanger it.
2016 Fear vs Hope: Gene Editing— Terrible turning point?by Pete ShanksDeccan ChronicleJanuary 1st, 2017As the tools for gene editing rapidly advance, we approach our best chance to prevent the rise of a modern, uncontrolled and dangerously ill-considered techno-eugenics.
Unexpected Risks Found In Replacing DNA To Prevent Inherited Disordersby Jill NeimarkNPRJanuary 1st, 2017Scientists are increasingly concerned that "3-person IVF" techniques may allow flawed mitochondria to resurface and threaten a child's health.
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