Researchers analysed thousands of laboratory-made plasmids and discovered that nearly half of them had defects, raising questions of experimental reproducibility.
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That story describes the development of the famous HeLa cell line, grown from cancer tissue taken from a poor black woman without her consent, and brilliantly recorded by Rebecca Skloot in her best-seller The Immortal Life of Henrietta Lacks (Crown, 2010). But it also neatly summarizes a separate tale that has echoes of the HeLa case and raises many of the same ethical questions of consent and obligation. Until now, that story has failed to reach the broad audience it deserves.
The cell line in this case is called WI-38, in which the initials represent the Wistar Institute of Anatomy and Biology in Philadelphia, Pennsylvania, where the early work was done. WI-38 has arguably had an even bigger impact on science and medicine than the HeLa...