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The first uterus transplant in the United States has failed, and the organ was surgically removed on Tuesday, officials at the Cleveland Clinic said on Wednesday.

The recipient, a 26-year-old woman, suddenly developed a serious complication on Tuesday, according to Eileen Sheil, a spokeswoman for the clinic. She did not specify the nature of the problem but said the uterus was being analyzed by pathologists to determine what went wrong.

The transplant, which used a uterus from a woman in her 30s who had died suddenly, was performed on Feb. 24. It was the first of 10 uterine transplants planned by the clinic, in an experimental program meant to enable women without a uterus to become pregnant and give birth. In a statement released Wednesday afternoon, the clinic said it would continue that effort.

“The study, which has been planned to include 10 women, is still ongoing with a commitment to the advancement of medical research to provide an additional option for women and their families,” the clinic said.

The failure occurred only a day after the clinic...