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It is premature to fight malaria, Zika, Lyme and other diseases with genetically engineered insects or other animals that have been designed to spread their modified genes in the wild, according to an expert panel convened by the National Academies of Science, Engineering and Medicine.

But the group, saying such a “gene drive” offers promise in combating diseases or saving endangered species, concluded that experimental research should continue, including carefully controlled field tests.

The panel's report, released Wednesday, has no force of law but will likely be influential in the debate about how, when and whether to use gene-drive technology to suppress the spread of pathogens. It comes amid mounting concerns about the Zika virus, which can be spread by mosquitoes and is linked to a spike in birth defects in South America.

The National Academies formed the group in response to the recent development of gene-drive techniques. The field of biotechnology is in the midst of a revolution, in part due to a new gene-editing tool known as CRISPR, which mimics a system invented by bacteria to defend themselves against...