Barbara Zeughauser had lost so many relatives to cancer: Her mother, her uncle, her grandmother, her second cousin. She thought that ghost in the family line might come after her, too. So in 2009, Zeughauser took a test offered by Myriad Genetics. It analyzed her DNA for mutations in the BRCA1 and BRCA2 genes that can make cancer more likely than not, raising the lifetime risk of breastcancer in women to between 55 and 85 percent, and to between 10 and 70 percent for ovariancancer.
Zeughauser was lucky and unlucky. She got a clear, unambiguous, and accurate answer from the test: She had a bad mutation. But she’d found it before she got cancer. She decided to have her ovaries removed and later had a double mastectomy, reducing her risk to almost average.
Her cousin Ken Deutsch wasn’t so lucky. In 2014, he was hit with bladder cancer. He also went...
The U.S. Food and Drug Administration (FDA) is supposed to encourage effective medical advances while also ensuring that patients and research subjects are protected. This dual mandate demands tricky judgment calls that are made more difficult by outside pressures of several kinds, political, judicial, and especially commercial. This April story at Bloomberg examines one deeply troubling pattern of regulatory capture:
Americans Are Paying Billions to Take Drugs That Don’t Work
Companies are increasingly...
Uyghurs, a predominantly Muslim minority in China, are mainly located in the autonomous region of Xinjiang. The Chinese government has pursued an aggressive settlement policy in this region since 1949, with the percentage of Han Chinese in the region increasing from five to forty percent in the second half of the 20th century. Since 2014, the Uyghurs have been subject to persecution and re-education – various sources have estimated that at least one million...
Louise Perry’s recent article in The Spectator cautions against “The quiet return of eugenics,” a threat she locates in preimplantation genetic testing for polygenic disorders. The technology is billed as a way for parents undergoing IVF to select which embryo to implant based on information about each embryo’s genetic risk factors and traits. These reports, she says, give parents “a very full picture of the adult that embryo could become”––from their child’s risk of developing different diseases to their “likely...
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