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Stem cell scientists at Stanford University in California announced "a huge step forward" last night, with the publication of research that turned skin into nerve cells without any intermediate step.

The production of neurons [nerve cells] directly from other adult cells, without making stem cells en route, could transform "regenerative medicine" - providing a plentiful supply of neurons for treating people with degenerative brain diseases such as Parkinson's or those with spinal injuries.

"We actively and directly induced one cell type to become a completely different cell type," said Marius Wernig of Stanford's Institute for Stem Cell Biology and Regenerative Medicine. "These are fully functional neurons. They can do all the principal things that neurons in the brain do."

This includes making connections with and signalling to other nerve cells - critical functions if the cells are eventually to be used as therapy for brain disease. The study is published online in the journal Nature .

Although research had suggested that specialised cells could be coaxed to show properties of other cell types, this is the first time skin cells...