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Have you heard this one? A sociologist, a lawyer, and a biologist walk into a bar, scoot their stools up to the counter, order drinks, and begin to chat. Suddenly, a booming voice (God, the bartender?) envelops them. “What is the meaning of race?” the voice asks.

While the question may seem straightforward on its face, it quickly spawns further questions, often vexing. Is race purely a political construct, or is it biologically encoded? Certainly there are aspects of human biology—skin color, hair color, the presence or absence of epicanthic folds, etc.—that are commonly associated with racial differences, but is race just the sum of these physical features, with all of the overlaps, exceptions, and ambiguities they involve? How do genes factor into the story? And what connection—if any—is there between biological markers of race and the social experiences of racial groups?

Each of the three drinking buddies has a lot to say to God or Sam Malone, and, by the way, their responses don’t end in laugh lines. The biologist, Richard Francis, engages other issues, though his concerns directly...